These Top 5 Prostate Supplements Can Help Reduce the Frequent Urinary Urges Waking You Up Every Night
If you are over 50 and sudden bladder urges throughout the night are depriving you of sleep, the underlying cause is probably not that extra glass of water you had too close to bedtime. An enlarged prostate is likely to blame.
For men in their 20s and 30s, the prostate is typically the size of a walnut. However, starting in the early 40s, this tiny reproductive organ begins to grow, often reaching the size of a lemon or even a grapefruit by age 60. As it expands, the gland presses against the bladder wall, causing frequent urinary urges and the sensation of a constantly full bladder. In addition, because the prostate surrounds the urethra, it restricts the flow of urine as it enlarges, resulting in a weak, dribbling stream and even issues in the romantic department.
While an enlarged prostate is a natural consequence of aging, free radical damage caused by environmental and dietary factors can accelerate prostate growth. However, a diet rich in antioxidants and a well-rounded supplement can help reduce frequent urination and protect against BPH issues as you grow older.
How Can You Tell Which Products Are Good or Bad for the Prostate?
Recent studies have indicated that more than half of men over age 50 and 80% of men over age 70 suffer from an enlarged prostate. Perhaps it is no surprise, then, that public demand for prostate supplements is growing rapidly.
When Will You See Results?
The ingredients in most prostate health products can provide some noticeable relief within 30 days. However, it may take additional time to establish an effective antioxidant defense against the free radicals which accelerate prostate growth and worsen urinary issues.
Research suggests that 3 months of daily use helps significantly increase the likelihood of lasting improvement. Here is a reasonable timeline to expect:
Month 1: You may feel that you can more completely empty your bladder, allowing you to sleep longer through the night with fewer interruptions.
Month 2: You may notice a stronger urine stream, resulting in less dribbling and straining each time you visit the bathroom.
Month 3: Peak prostate support is reached. You may experience significantly fewer urinary urges both at night and during the day, better control over your bladder, and more confidence in the bedroom.
Tip: For best results, focus on consistency. Adding an effective prostate supplement to your daily routine for at least 3 months promotes exponential improvement, as each dose builds on the benefits of the last.
So, what characteristics distinguish top-tier prostate products from the rest of the pack
The 7 Must-Have Ingredients for a Good Prostate Supplements
Zinc ( as zinc gluconate )
Alpha Lipoic Acid
Green Tea ( camellia sinensis) Leaf Extract
Milk Thistle ( selybum marianum ) Seed Extract
Berberine ( from berberis aristata root )
Resveratrol ( from polygonum cuspidatum root extract)
Ginseng ( panax ginseng) Extract
Warning Signs of Potential Scams
- Lack of Clinical Studies
Be cautious of brands that highlight individual ingredients instead of proving the product’s overall effectiveness.
The gold standard for any supplement is a placebo-controlled clinical trial conducted by an independent third party.
- Unproven Ingredients
Only a handful of natural ingredients truly boost testosterone effectively and safely.
Many so-called boosters rely on herbs with little to no clinical backing.
Be wary of supplements that pack in long ingredient lists just to look impressive — more isn’t always better.
In fact, some products we reviewed had over 10 different ingredients, most with questionable value.
Below, we break down our rankings and feature detailed reviews of the 5 best prostate supplements we analyzed, beginning with our top pick.
1. ProstaBliss
973 votes TOTAL RANKING
A+
Overall Grade
Pros
- Contains all 9 must-have ingredients
- No fillers or artificial additives
- Vegan, non-GMO, and gluten-free
- Molecular formula similar to others on the market without the side effects.
- Vegan, non-GMO, and gluten-free
- Made in the USA in an FDA Approved facility.
- 60-Day Money Back Guarantee
Cons
- Anyone under the age of 18 not recommended
- Only available on the official website, not in physical stores
- Due to high demand, the product is in limited stock on the website
The Bottom Line
We gave ProstaBliss by Nutreance our #1 ranking because it is the only prostate supplement that meets every one of our strict criteria.
ProstaBliss was clinically tested for safety and effectiveness over the course of 30 days in a placebo-controlled clinical trial conducted by Princeton Consumer Research. The study showed that people taking Prostate Max experienced significantly fewer urinary urges and improved bladder emptying compared with placebo, allowing participants to sleep throughout the night without interruption.
ProstaBliss contains all 5 of the ingredients we consider essential for optimal prostate support, including a Zinc , Alpha Lipoic Acid, Green Tea, milk Thistle, Berberine, Resveratrol and Ginseng.It is also produced in a GMP-certified laboratory in New York.
It is available on Amazon.com, but we found significantly better discounts and shipping options to Brazil on Nutreance’s website. The company also offers other products to help protect your mind and body as you age, including a natural cognitive enhancer and a joint support supplement.
Overall, ProstaBliss is our top pick for prostate health in 2025.
Click here to visit the product website.
Overall, ProstaBliss is our top pick 2025.
Click here to visit the product website.
2. Prostafense
647 votes TOTAL RANKING
A-
Overall Grade
Pros
- Contains 3 out of 5 must-have ingredients
- No artificial additives
- Vegan, non-GMO, and gluten-free
- Made in the USA
Cons
- No clinical study
- Limited scientific research backing the overall efficacy of the formula as a whole.
- Users report an unpleasant aftertaste when consuming Alpha Force.
- Contains some ingredients with questionable efficacy and safety.
- May take longer to show noticeable results compared to similar products.
The Bottom Line
Prostafense by Designs for Health technically contains 4 of the essential ingredients that we look for in an effective prostate support supplement, including beta-sitosterol, saw palmetto, stinging nettle, and lycopene. However, it should be noted that the beta-sitosterol content is provided by stinging nettle extract rather than a separate phytosterol complex, limiting the total quantity of beta-sitosterol within the formula. Because pumpkin seed is not included, the product’s efficacy primarily depends on just 3 antioxidants.
To compensate for this, Prostafense contains L-glycine, L-alanine, and L-glutamic acid, 3 amino acids shown to benefit men with BPH-related urinary issues in a 1958 study. However, only 40 men participated, and subsequent clinical trials have failed to replicate these results. Also included is chrysin, which is suggested to reduce prostate growth by modulating hormone levels. Unfortunately, the research supporting this ingredient has focused on rodents so far.
The product has not been evaluated for safety and effectiveness in a placebo-controlled clinical study, which could justify the inclusion of amino acids and hormone stabilizers rather than additional antioxidants.
Click here to visit the product website
487 votes TOTAL RANKING
B-
Overall Grade
Pros
- Contains 2 out of 5 must-have ingredients
- No fillers or artificial additives
- Vegan, non-GMO, and gluten-free
- Made in the USA
Cons
- No clinical study
- Some users report mild side effects like headaches or stomach discomfort
- Contains some ingredients with questionable efficacy and safety.
The Bottom Line
Concentrated Ultra Prostagen by Metagenics includes 4 essential ingredients for a stronger stream: beta-sitosterol, saw palmetto, stinging nettle, and lycopene. While beta-sitosterol is not indicated on the label, the saw palmetto in the formula is standardized to yield 45% fatty acids and sterols, with beta-sitosterol providing the majority of that sterol content.
Like Prostate Supreme, Concentrated Ultra Prostagen includes the amino acid complex of L-glycine, L-alanine, and L-glutamic acid. As indicated previously, these 3 ingredients showed some benefit for the participants in a small-scale study. However, the medical community’s clinical understanding of BPH, as well as statistical standards for efficacy, have changed dramatically since the trial took place in the 1950s.
Instead of pumpkin seed, a natural source of the anti-inflammatory mineral zinc, Metagenics opted to add zinc citrate to the formula. This overlooks the other compounds provided by pumpkin seed which support prostate health, including carotenoids and plant sterols.
Lastly, they have not tested the product for effectiveness in a clinical study.
Click here to visit the product website.
4. Prostate FLO
429 votes TOTAL RANKING
C
Overall Grade
Pros
- Claims to boost energy and performance
- No fillers or artificial additives
- Vegan, non-GMO, and gluten-free
- Made in the USA
Cons
- No clinical study
- Does not contain stinging nettle, lycopene, or pumpkin seed
- Contains ingredients with questionable efficacy
The Bottom Line
Prostate FLO by Xymogen features 2 of the most essential ingredients for prostate support, beta-sitosterol and saw palmetto, plus 4 other compounds to help reduce bladder urges.
The formula prominently contains cranberry fruit solids, which are frequently taken for relief from urinary tract infections. While clinical trials have established their effectiveness for this purpose, there is little evidence they can reduce frequent urination caused by an enlarged prostate.
The product also features pygeum, the bark of the African cherry tree, which is rich in hormone stabilizing compounds and has been shown to improve urine flow in several studies. Upon further analysis, however, the most promising studies tested a combination therapy of pygeum and stinging nettle, while pygeum alone produced statistically insignificant results. Regrettably, Prostate FLO does not contain stinging nettle, nor does it include lycopene or pumpkin seed.
Perhaps most importantly, the product as a whole has not been tested by an independent, third-party clinical study.
Click here to visit the product website.
Our Rating
C-
Overall Grade
Pros
- Contains huperzine A
- No fillers or artificial additives
- Non-GMO and gluten-free
- Made in the USA
Cons
- No clinical study
- May contain beta-sitosterol but lacks a standardized source
- Does not contain beta-sitosterol, lycopene, or pumpkin seed
The Bottom Line
Prostatrol Forte by Ortho Molecular Products contains saw palmetto and stinging nettle, both crucial antioxidants to reduce frequent urges. The formula also features several minerals for prostate health, as well as pygeum. Unlike Prostatrol Forte, the bark extract is paired with stinging nettle in an attempt to replicate the efficacy seen in clinical trials of the combination therapy.
While Ortho Molecular Products has put some components in place for a promising supplement, they neglected to include a dedicated source of beta-sitosterol, which is the most essential ingredient for relief from frequent urination and incomplete bladder emptying. Typically, saw palmetto and stinging nettle contain beta-sitosterol. However, in this formula, neither is specifically standardized to provide this critical ingredient. Since beta-sitosterol content can vary widely by source, Prostatrol Forte cannot be relied upon to provide sufficient beta-sitosterol to benefit the prostate.
With lycopene and pumpkin seed also missing, a clinical study would go a long way to validate the formula’s efficacy. Unfortunately, none have been conducted yet for this product.
Click here to visit the product website.
For all products featured, results may vary. Please visit the product websites for further information.
These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure, or prevent any disease.
The information on this website is not intended as a substitute for professional medical advice. If you have, expect to have, or suspect you may have any medical condition, we recommend you consult with a physician.
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